NTRK fusion genes

NTRK fusion genes occur when parts of the NTRK gene combine with other genes, creating an abnormal gene that produces a continuously active protein. This protein signals cells to grow and divide uncontrollably, which can lead to certain types of cancers. These gene fusions are rare but important because they can be targeted with specific therapies called NTRK inhibitors. Detecting NTRK fusions helps doctors choose personalized treatments that may be more effective for patients with tumors harboring these genetic changes.