neuropathological grading

Neuropathological grading is a way scientists evaluate the severity of brain diseases, like Alzheimer's or Parkinson’s, by examining tissue samples under a microscope. They look at specific features—such as the amount of abnormal protein buildup, cell loss, or scarring—and assign a grade (often from mild to severe). This helps determine how advanced the disease is, guiding diagnosis, prognosis, and potential treatment options. Essentially, it’s a standardized method for objectively measuring disease progression based on physical changes in brain tissue.