Negishi coupling

Negishi coupling is a chemical reaction used to connect two organic molecules, specifically forming a bond between a carbon atom of one molecule and a metal catalyst, usually zinc. The process involves transforming one molecule into a reactive form (organometallic reagent) and then combining it with another molecule containing a halogen (like iodine or bromine). The catalyst facilitates the formation of a new carbon-carbon bond, creating more complex compounds. This reaction is valuable in the synthesis of pharmaceuticals, natural products, and advanced materials because it allows precise and efficient construction of complex molecular structures.