NEDD8-activating enzyme

The NEDD8-activating enzyme is a crucial component in a cellular process called neddylation, which tags proteins with the molecule NEDD8. This tagging modifies the proteins' activity, stability, or interactions, helping regulate essential functions like cell growth and division. The enzyme specifically activates NEDD8 by attaching it to a carrier molecule, setting the stage for its transfer to target proteins. Proper functioning of this enzyme is vital for maintaining cell health, and disruptions can be linked to diseases such as cancer. Essentially, it acts as a key initiator that enables NEDD8 to perform its regulatory role in the cell.