NAD+-dependent deacetylation

NAD+-dependent deacetylation is a biological process where certain enzymes, called sirtuins, remove acetyl groups from proteins, affecting their activity. This reaction relies on NAD+ (nicotinamide adenine dinucleotide), a molecule that provides the necessary energy and electrons. When sirtuins use NAD+ to remove acetyl groups, it helps regulate important functions like gene expression, aging, and metabolism. Essentially, NAD+ acts as a fuel that powers these enzymes, linking the cell's energy status to its ability to control protein activity and maintain overall health.