N-terminal APP domains

The N-terminal domains of the Amyloid Precursor Protein (APP) are the parts of the protein located at its beginning (or amino end) outside the cell. These domains play important roles in cell communication, growth, and protection within the nervous system. They help APP interact with other molecules on the cell surface and influence processes like cell signaling and adhesion. Understanding these domains is crucial because they influence how APP functions and how its breakdown may lead to the production of amyloid-beta, which is associated with Alzheimer's disease.