Multiple reaction monitoring (MRM)

Multiple Reaction Monitoring (MRM) is a precise analytical technique used in mass spectrometry to detect and measure specific molecules within complex samples. It works by first selecting a particular molecule (precursor ion), then breaking it into smaller pieces, and finally monitoring a specific fragment (product ion). By focusing only on these targeted transitions, MRM offers high sensitivity and specificity. This makes it ideal for accurately quantifying specific compounds, such as drugs or biomarkers, even when they are present at very low levels amid many other substances.