MITF (melanocyte-inducing transcription factor)

MITF (Microphthalmia-associated transcription factor) is a protein that acts like a master switch for certain cells, especially melanocytes—the cells responsible for producing pigment in the skin, hair, and eyes. It regulates the activity of genes involved in cell growth, survival, and pigment production. Essentially, MITF ensures that melanocytes develop properly and function correctly. Besides pigmentation, it also plays a role in other cell types, including some involved in immune responses and cancer. Proper regulation of MITF is crucial for healthy pigmentation, and its malfunction can contribute to disorders like melanoma or pigmentation abnormalities.