Metachromatic leukodystrophy

Metachromatic leukodystrophy (MLD) is a rare genetic disorder that affects the brain and nervous system. It results from the body's inability to break down a fatty substance called sulfatide, causing these fats to accumulate in nerve cells. This buildup damages the protective covering around nerves, called myelin, leading to progressive problems with movement, coordination, and cognitive functions. Symptoms often appear in childhood but can also begin in adulthood. MLD is inherited, meaning it runs in families, and currently has no cure, though treatments may help manage symptoms and improve quality of life.