Mendelian Susceptibility to Mycobacterial Disease (MSMD)

Mendelian Susceptibility to Mycobacterial Disease (MSMD) is a rare genetic condition where the immune system has a specific weakness in fighting certain bacteria, like the ones causing tuberculosis and related infections. This happens because of inherited gene mutations that impair the immune response, particularly the ability to produce certain immune signals called interferons. As a result, individuals with MSMD are more prone to persistent or serious infections from these bacteria, even if their overall immune system seems healthy. Understanding MSMD helps doctors provide targeted treatments and manage these specific infections effectively.