Lymphocyte Homing

Lymphocyte homing is the process by which immune cells called lymphocytes travel through the bloodstream to specific tissues, such as lymph nodes or areas of infection. They follow chemical signals and interact with specialized blood vessel walls, known as high endothelial venules, which express specific molecules that guide lymphocytes to their target sites. This targeted movement allows the immune system to efficiently detect and respond to pathogens or abnormal cells, ensuring that immune responses occur where they are needed most. Essentially, lymphocyte homing is the immune system’s GPS system directing immune cells to the right locations.