Lipotoxicity

Lipotoxicity refers to the harmful effects that occur when excess fat or fat-related substances accumulate in tissues like the liver, heart, or pancreas. Normally, these tissues use or store fats safely, but when fat levels become too high, it can lead to cellular stress and damage. This process is linked to conditions like type 2 diabetes, fatty liver disease, and heart disease. Essentially, lipotoxicity shows how too much fat in certain parts of the body can disrupt normal cell functions and contribute to disease development.