Light chain gene rearrangement

Light chain gene rearrangement is a process within immune cells that produces diverse antibodies. B cells, a type of immune cell, generate unique antibodies by combining gene segments called V (variable), J (joining), and sometimes D (diversity) segments. During development, these segments are rearranged or shuffled to create a vast variety of antibodies capable of recognizing many different invaders. Specifically for light chains, the rearrangement involves selecting and joining V and J segments to form a functional gene that produces a specific light chain protein. This diversity is essential for the immune system’s ability to identify and neutralize a wide range of pathogens.