Leber congenital amaurosis (LCA)

Leber congenital amaurosis (LCA) is a rare genetic disorder that causes severe vision loss or blindness from birth or early infancy. It results from mutations in genes essential for the development and function of the retina, the light-sensitive tissue at the back of the eye. Individuals with LCA often have poor visual responses, nystagmus (involuntary eye movements), and difficulty focusing. While there is no cure, some gene therapies and supportive treatments can help improve vision or slow progression. Early diagnosis and intervention are important for managing the condition and supporting affected individuals.