LAL assay

The Limulus Amebocyte Lysate (LAL) assay is a sensitive test that detects bacterial contamination, specifically endotoxins from Gram-negative bacteria, in medical and pharmaceutical products. It uses blood extract from horseshoe crabs, which clots in the presence of these toxins. When a sample is added to the LAL reagent, a rapid clotting reaction indicates endotoxin presence, signaling potential contamination. This test is essential for ensuring the safety of injectable drugs, vaccines, and surgical materials, providing a quick and reliable way to monitor for harmful bacteria before products reach patients.