Koshland-Nemethy-Filmer model

The Koshland-Nemethy-Filmer (KNF) model describes how enzymes change shape when they bind to a substrate. It suggests that enzymes are flexible molecules that undergo specific shape shifts to fit the substrate better. These conformational changes happen gradually, with parts of the enzyme adjusting to facilitate binding and catalysis. Unlike models that assume enzymes have a fixed shape, KNF emphasizes the dynamic, adaptable nature of enzymes, which enhances their ability to recognize and process different molecules efficiently. This model helps explain the high specificity and versatility of enzyme activity in biological systems.