KMT2A (MLL)

KMT2A, also known as MLL, is a gene that produces a protein involved in regulating how genes are turned on and off, particularly during cell growth and development. When functioning normally, it helps ensure cells grow and differentiate correctly. However, if KMT2A undergoes mutations or rearrangements—such as in certain leukemias—it can disrupt gene regulation, leading to uncontrolled cell division and cancer. These genetic changes are often found in aggressive blood cancers like leukemia, making KMT2A an important focus for understanding disease mechanisms and developing targeted therapies.