Keap1 (Kelch-like ECH-associated protein 1)

Keap1 (Kelch-like ECH-associated protein 1) is a protein that plays a critical role in protecting cells from oxidative stress and damage. It acts as a regulator for a protein called Nrf2, which controls the expression of genes involved in defense mechanisms against stress. Under normal conditions, Keap1 binds to Nrf2 and promotes its degradation, preventing unnecessary activation. When cells experience oxidative stress, Keap1 releases Nrf2, allowing it to activate protective genes. This process helps cells adapt and survive in challenging environments, maintaining cellular health and preventing damage that could lead to disease.