KEAP1

KEAP1 (Kelch-like ECH-associated protein 1) is a protein that helps regulate how our cells respond to stress by controlling a key factor called NRF2. Under normal conditions, KEAP1 binds to NRF2 and marks it for destruction, preventing it from activating protective genes. When cells face stress, KEAP1 releases NRF2, allowing it to enter the nucleus and turn on genes that help protect cells from damage. This process is crucial for maintaining cellular health and preventing diseases like cancer and neurodegeneration.