JMJD2

JMJD2, also known as KDM4, is a type of enzyme called a histone demethylase. It plays a key role in gene regulation by removing methyl groups from histones—proteins around which DNA is wound. This process influences how tightly DNA is packed, affecting whether genes are turned on or off. JMJD2's activity is important for normal cell function, development, and DNA repair. Abnormal regulation of JMJD2 has been linked to diseases like cancer, making it a target of interest for potential therapies that aim to modify gene expression patterns.