Irreversible inhibitors

Irreversible inhibitors are substances that permanently bind to an enzyme, preventing it from functioning. They often attach through strong, covalent bonds, effectively inactivating the enzyme by modifying its active site—the region where chemical reactions occur. Once bound, the enzyme cannot recover its activity, which can decrease the overall reaction rate in the body. These inhibitors are used in some medications and research to block specific enzyme actions, providing a lasting effect compared to reversible inhibitors, which bind temporarily and can detach, allowing enzyme activity to resume.