Irreversible inhibition

Irreversible inhibition occurs when a substance binds permanently to an enzyme, effectively deactivating it. This process often involves forming a strong, lasting bond with the enzyme’s active site, preventing the enzyme from catalyzing its normal reactions. Because the bond is permanent, the enzyme cannot be regenerated, reducing the overall amount of active enzyme available in the system. This type of inhibition is used in certain medications, like antibiotics, to permanently disable harmful enzymes, ensuring the pathogen can no longer function or reproduce effectively.