In Situ Hybridization

In Situ Hybridization (ISH) is a laboratory technique used to locate specific DNA or RNA sequences within cells or tissue sections. It involves applying a labeled complementary strand of genetic material (probe) that binds selectively to the target sequence. Under a microscope, scientists can see exactly where the genetic material is located, which helps in studying gene expression, diagnosing diseases like cancer, and understanding cellular functions. Essentially, ISH is like a molecular GPS that reveals the precise position of specific genes or molecules inside cells.