IgG4-related sclerosing cholangitis

IgG4-related sclerosing cholangitis is an immune condition where the body’s immune system causes inflammation and scarring of the bile ducts, which carry bile from the liver to the intestines. This inflammation can lead to blockages, causing symptoms like jaundice (yellowing of the skin and eyes), abdominal pain, and abnormal liver tests. It's part of a larger group of diseases involving IgG4, a specific type of antibody. The condition often responds well to steroid treatment. Accurate diagnosis is important to distinguish it from other bile duct diseases, such as cancer, to ensure proper management.