IDH1 Mutation

An IDH1 mutation involves a change in the IDH1 gene, which produces an enzyme that helps cells process nutrients. Normally, this enzyme helps convert a molecule called isocitrate into other substances needed for cell health. When this gene is mutated, it causes the enzyme to produce an abnormal substance called 2-hydroxyglutarate, which can interfere with normal cell functions and potentially lead to uncontrolled cell growth. Such mutations are often found in certain types of brain tumors, like gliomas, and are important for diagnosis, prognosis, and treatment planning.