IDH1/IDH2 Mutations

IDH1 and IDH2 mutations are changes in genes that produce enzymes involved in cell metabolism. These enzymes normally help convert nutrients into energy and building blocks for cells. When mutated, they produce an abnormal substance called 2-hydroxyglutarate, which can interfere with normal cell function and promote the development of certain cancers, like gliomas and leukemia. Understanding these mutations helps doctors diagnose, predict outcomes, and develop targeted treatments, as drugs can be designed to block the effects of these abnormal enzymes and potentially improve patient outcomes.