hyperimmunoglobulinemia D with recurrent fever syndrome

Hyperimmunoglobulinemia D with recurrent fever syndrome (HIDS) is a rare genetic condition where the immune system produces too much of a protein called immunoglobulin D (IgD). This leads to episodes of high fever, painful swelling, and inflammation, often occurring repeatedly. The underlying cause involves a mutation affecting immune regulation, causing the body's defenses to become overactive during episodes. While these attacks can be intense, they usually resolve on their own. Managing HIDS often includes medications to reduce inflammation and prevent attacks, helping improve quality of life for affected individuals.