HGPRT (Hypoxanthine-guanine phosphoribosyltransferase)

HGPRT (Hypoxanthine-guanine phosphoribosyltransferase) is an enzyme involved in recycling certain nitrogenous waste products—specifically, hypoxanthine and guanine—by converting them back into useful building blocks called nucleotides, which are essential for DNA and RNA synthesis. It plays a critical role in maintaining the balance and supply of purines in cells. When HGPRT is defective or missing, as in certain genetic disorders like Lesch-Nyhan syndrome, the body cannot properly recycle purines, leading to waste buildup and associated symptoms such as neurological issues and behavioral problems.