HFE gene

The HFE gene provides instructions for making a protein involved in regulating how much iron is absorbed from food in the intestines. Proper function of this gene helps maintain balanced iron levels in the body. Mutations in the HFE gene can lead to hereditary hemochromatosis, a condition where the body absorbs too much iron, potentially causing damage to organs over time. So, the HFE gene plays a key role in managing iron homeostasis, and variations can influence an individual’s risk for iron overload disorders.