HDAC Inhibition

HDAC inhibition involves blocking enzymes called histone deacetylases (HDACs), which normally remove acetyl groups from proteins called histones tied to DNA. When HDACs are active, they tighten DNA packaging, reducing gene expression. Inhibiting HDACs relaxes the DNA structure, allowing genes to be more easily activated. This process can influence cell behavior, making HDAC inhibitors useful in treating certain cancers and neurological disorders by promoting the expression of beneficial genes, controlling abnormal cell growth, or reducing inflammation.