Harbison et al. (2004) study on yeast transcription factors

Harbison et al. (2004) conducted a study mapping how yeast transcription factors—proteins that regulate gene activity—bind to DNA across the entire yeast genome. Using a technique called ChIP-chip, they identified the specific DNA regions where these factors attach, revealing how gene expression is controlled. Their work created a comprehensive “regulatory map,” showing the complex interactions among transcription factors and genes. This enhanced understanding of gene regulation mechanisms in yeast, which can serve as a model for similar processes in higher organisms.