H3K27 methylation

H3K27 methylation is a chemical modification where methyl groups are added to the 27th amino acid (lysine) of the histone protein H3, around which DNA is wrapped. This process influences gene activity by tightening the DNA-histone interaction, effectively turning genes off or reducing their expression. It plays a critical role in regulating development, cell identity, and maintaining normal cellular functions. Abnormal H3K27 methylation is linked to various diseases, including cancers, highlighting its importance in gene regulation and cellular health.