Genetic abnormalities in multiple myeloma

Genetic abnormalities in multiple myeloma refer to changes in the DNA of the cancerous plasma cells, such as mutations, deletions, or extra copies of certain genes. These changes can affect how the cells grow and survive, influencing the disease's behavior and response to treatment. Common abnormalities include translocations (where parts of different chromosomes swap places) and deletions of tumor suppressor genes. Understanding these genetic changes helps doctors predict the disease course and tailor therapies for better management.