FUS (Fused in Sarcoma)

FUS (Fused in Sarcoma) is a gene that produces a protein involved in DNA repair and cell regulation. In some cases, mutations or abnormal changes in the FUS gene lead to the production of defective proteins, which can accumulate abnormally in nerve cells. This accumulation is linked to certain neurodegenerative diseases, notably forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). These conditions impair nerve cell function, leading to symptoms like muscle weakness, paralysis, or cognitive decline. Understanding FUS helps researchers explore the underlying causes of these diseases and develop potential treatments.