functional selectivity

Functional selectivity, also known as biased signaling, refers to the way a receptor—like those in your body’s cells—can trigger different responses depending on the specific molecule (ligand) that binds to it. Instead of activating all its possible pathways equally, certain compounds can selectively influence only some pathways, leading to specific effects. This allows for more targeted actions, potentially reducing side effects, because the receptor can be fine-tuned to produce desired outcomes while avoiding others. It’s a nuanced way cells communicate, offering opportunities for more precise drug development.