Fragile X Chromosome

A fragile X chromosome is a variation of the X chromosome that has a specific area prone to a gap or break, making it unstable. This occurs because of an abnormal repetition of a DNA sequence called CGG. When these repeats become too numerous, it can lead to Fragile X syndrome, a genetic condition causing intellectual disabilities, learning challenges, and behavioral issues. It is inherited in an X-linked pattern, meaning it mostly affects males, but females can also be carriers or be affected. This condition is the most common inherited cause of intellectual disability.