Folate antagonists

Folate antagonists are drugs that block the activity of folate, a vital nutrient involved in DNA and cell growth. Since rapidly dividing cells, like bacteria or cancer cells, need folate to reproduce, these medications hinder their growth. They are often used as antibiotics or cancer treatments, disrupting the cells’ ability to multiply by interfering with folate-dependent processes essential for DNA synthesis. Examples include methotrexate and trimethoprim. By targeting folate pathways, these drugs specifically affect fast-growing cells, helping to control infections or limit cancer progression.