Fmoc protection strategy

Fmoc protection is a chemical technique used in peptide synthesis to selectively protect amino acids. The Fmoc group (fluorenylmethyloxycarbonyl) is attached to the amino group of an amino acid, preventing it from reacting during chain assembly. This temporary "block" can be easily removed with a mild base (like piperidine) when desired, allowing the amino acid to continue forming a peptide chain. This method offers precise control, high efficiency, and minimal side reactions, making it a popular choice for constructing complex peptides in research and pharmaceutical development.