EZH2 (Enhancer of Zeste 2)

EZH2 (Enhancer of Zeste 2) is a protein that functions as an enzyme involved in gene regulation. It is a core component of the Polycomb Repressive Complex 2 (PRC2) and adds methyl groups to specific histone proteins, leading to the tight packing of DNA. This process effectively suppresses gene activity, playing a vital role in cell development, differentiation, and maintaining cellular identity. Aberrant EZH2 activity has been linked to various cancers, making it a target for potential therapeutic interventions to restore normal gene expression patterns.