Extranodal manifestations

Extranodal manifestations refer to instances where diseases, such as lymphoma or infections, affect tissues or organs outside of the lymph nodes. Instead of originating in or spreading between lymph nodes, these illnesses directly involve areas like the skin, lungs, gastrointestinal tract, or brain. Recognizing extranodal involvement is important for accurate diagnosis, staging, and treatment planning, as it can influence the severity and course of the disease. Essentially, it indicates that the disease has spread beyond its usual lymphatic system location into other parts of the body.