Estrogen Plus Progestin Study

The Estrogen Plus Progestin Study, also known as the Women's Health Initiative (WHI), was a large clinical trial conducted from 1993 to 2002 to assess the health effects of hormone therapy in postmenopausal women. It primarily examined whether taking estrogen combined with progestin could reduce conditions like osteoporosis and heart disease. Surprisingly, the results showed increased risks of breast cancer, heart attacks, strokes, and blood clots, leading to recommendations against routine hormone therapy for prevention. The study provided critical insights into the risks and benefits of hormone therapy, influencing medical guidelines and women's health decisions.