Ehrlich Equation

The Ehrlich equation describes how the effectiveness of an enzyme inhibitor depends on the concentration of the inhibitor and how tightly it binds to the enzyme. It’s expressed as \( I = \frac{\text{IC}_50}{1 + \frac{[S]}{K_m}} \), where \( I \) is the inhibitor concentration, \( \text{IC}_50 \) is the concentration needed to inhibit 50% of the enzyme activity, \([S]\) is the substrate concentration, and \( K_m \) is the substrate’s affinity for the enzyme. This equation helps predict how changing inhibitor or substrate levels influence enzyme activity, aiding in drug design and understanding enzyme behavior.