E4 allele (APOE ε4)

The E4 allele (APOE ε4) is a genetic variation of the APOE gene, which influences how the body processes fats and cholesterol. Having this allele increases the risk of developing Alzheimer’s disease, a condition that affects memory and thinking skills, especially as people age. Not everyone with the E4 allele will develop Alzheimer’s, but it is considered a significant genetic risk factor. It’s one piece of the genetic puzzle that, along with lifestyle and environmental factors, can impact brain health over time.