Dutch familial hypercholesterolemia variant

Dutch familial hypercholesterolemia (FH) variant is a genetic mutation common in the Netherlands that causes very high levels of LDL cholesterol ("bad" cholesterol). This condition is inherited from one or both parents and significantly increases the risk of early heart disease, such as heart attacks. People with this variant have fewer or defective LDL receptors, which normally help remove cholesterol from the blood. Identifying this specific genetic mutation allows for targeted treatment and early intervention to reduce cardiovascular risk, not only for affected individuals but also for their families through genetic screening.