DUBs (deubiquitinating enzymes)

Deubiquitinating enzymes (DUBs) are specialized proteins that remove ubiquitin molecules from other proteins. Ubiquitin acts like a molecular tag, marking proteins for various fates such as degradation or activity regulation. DUBs effectively edit or reverse these tags, controlling the stability, location, and function of proteins within the cell. They are essential for maintaining cellular balance and ensuring proper protein lifespan. By modulating ubiquitin signaling, DUBs play critical roles in processes like cell cycle regulation, DNA repair, and immune response, making them important for normal cell function and health.