DNA crosslinking

DNA crosslinking occurs when certain agents cause links between two strands or within the same strand of DNA, preventing them from separating properly. This can interfere with vital processes like replication and repair because the DNA strands need to unwound to copy or fix genetic information. Crosslinks can be caused by environmental factors, drugs, or chemicals, and they can lead to cell malfunction or death if not properly repaired. In essence, DNA crosslinking creates physical bridges that disrupt the normal structure and function of genetic material.