Desmoglein Antibodies

Desmoglein antibodies are proteins produced by the immune system that mistakenly target desmogleins, which are essential components of cell adhesion in the skin and mucous membranes. These antibodies can lead to conditions like pemphigus vulgaris, where the skin blisters and sores form due to the disruption of cell connections. In essence, desmoglein antibodies confuse the body’s defense system, attacking its own tissues, which can result in painful and serious skin problems. Detecting these antibodies helps doctors diagnose autoimmune diseases affecting the skin.