Desmoglein

Desmogleins are proteins that play a crucial role in maintaining the integrity and cohesion of skin cells. They are part of structures called desmosomes, which act like cellular glue, anchoring skin cells together to form a strong, resilient barrier. Desmogleins help cells stay connected, allowing the skin to resist mechanical stress and prevent tears or blistering. They are essential for the skin's structural stability and proper function. When desmogleins malfunction or are targeted by immune responses, it can lead to skin disorders characterized by blistering or loss of cell adhesion.