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Major depression, or major depressive disorder, is a mental health condition characterized by persistent feelings of sadness, loss of interest or pleasure in activities, and a range of physical and emotional symptoms such as fatigue, difficulty concentrating, changes in sleep and appetite, and feelings of worthlessness or hopelessness. These symptoms interfere significantly with daily life, relationships, and work. It is a common, serious illness that can be effectively treated with therapy, medication, or a combination of both. Early diagnosis and support are essential for managing the condition and improving quality of life.