Deletions of mitochondrial DNA

Deletions of mitochondrial DNA involve the loss of small segments of genetic material within mitochondria, the energy-producing parts of cells. Since mitochondria have their own DNA separate from the cell's nucleus, these deletions can impair how well mitochondria generate energy. This can lead to various health problems, especially in tissues with high energy needs like muscles and the brain. These deletions can occur naturally over time or due to exposure to certain factors, and they may contribute to aging or mitochondrial diseases, where energy production is compromised.